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Movies like Man's Best Friend

Key Features:
Animal cruelty, Science gone wrong, Genetic experiment, Dog, Violence-high, Survival, Thriller, Reporter, Animal rights, Unexpected consequences, Human experimentation, Hybrid creature
Tone:
serious, gritty, suspense-driven
Target Audience:
Horror fans, Thriller enthusiasts, Viewers interested in animal rights themes, Science fiction horror viewers
Emotional Arc:
Curiosity → Fear → Horror

Man's Best Friend

1993-11-19
Man's Best Friend Poster - Find Similar Movies

A genetic research facility worker exposes animal abuses there to a local TV reporter, who frees and takes in a genetically altered dog from the lab, unaware that he has a violent streak.

Genres
Horror, Science Fiction, Thriller, Comedy
Cast
Ally Sheedy, Lance Henriksen, Robert Costanzo, Fredric Lehne, John Cassini, J.D. Daniels, William Sanderson, Trula M. Marcus, Robin Frates, Rick Barker
Crew
John Lafia, John Lafia
Rating
5.9(135 votes)
Man's Best FriendMan's Best Friend
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Watchers
Watchers(1988)
5.3

A boy takes in a stray dog, later finding out that it's an ultra-intelligent runaway from a genetic research lab. Unbeknownst to him, the dog is being stalked by another escaped creature that's not quite so friendly.



DNA
DNA(1997)
4.008

A mad scientist's DNA experiment on the bones of a mysterious jungle creature brings the carnivorous beast to life, and only his former assistant Ash Mattley and CIA operative Claire Sommers can stop it.



Spiders
Spiders(2000)
4.899

A DNA experiment on a rare breed of spider is taking place on a NASA space shuttle, when a freak meteor shower engulfs the shuttle, causing everything to go horribly wrong. One survivor is found on the ship and watched over in a secret location deep in the California desert. The problem continues, as the survivor isn't alone, as another deadly spiders climbs out of him and goes on a rampage around the ship. Curious reporter Marci Eyre must now survive, escape and warn everyone before the spider reaches outside the desert.



White Dog
White Dog(1982)
6.634

A trainer attempts to retrain a vicious dog that’s been raised to kill black people.



The Breed
The Breed(2006)
5.454

Brothers John and Matt have inherited an island cabin from their recently deceased uncle. Along with Matt's girlfriend, Nicki, and other mutual friends, the siblings travel to the cabin for a relaxing weekend getaway. But, not long after arriving, the group is besieged by ravenous dogs. They watch in horror as another vacationer, Luke, is eaten alive. Soon, they discover a training facility where the dogs have been bred to kill.



Species
Species(1995)
6

In 1993, the Search for Extra Terrestrial Intelligence Project receives a transmission detailing an alien DNA structure, along with instructions on how to splice it with human DNA. The result is Sil, a sensual but deadly creature who can change from a beautiful woman to an armour-plated killing machine in the blink of an eye.



Splice
Splice(2010)
5.9

Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.



Pet
Pet(2016)
5.831

A man bumps into an old crush and becomes obsessed. After several failed attempts at winning her over, he kidnaps her and holds her captive underneath the animal shelter where he works.



The Plague Dogs
7.9

Two dogs, Rowf and Snitter, struggle to survive in the countryside after escaping from an animal research laboratory. They are pursued by search parties and then the military after rumors spread that they could be carrying the bubonic plague.



Forbidden World
5.224

In the distant future, a federation marshal arrives at a research lab on a remote planet where a genetic experiment has gotten loose and begins feeding on the dwindling scientific group.



Unnatural
Unnatural(2015)
4.11

Global climate change prompts a scientific corporation to genetically modify Alaskan polar bears with horrific and deadly results.



Good Boy
Good Boy(2020)
6.5

When Maggie gets an emotional support dog to help quell some of her anxiety, she finds him to be even more effective than she imagined... because unbeknownst to her, he kills anyone who adds stress to her life.



Mind Ripper
4.3

A top secret experiment intended to produce a superhuman has gone terribly wrong. Now the creators, trapped in a remote desert outpost, are being pursued ruthlessly by their creation.



Human Animals
6.778

The harmony of a seemingly idyllic neighborhood is disrupted when a dog attacks a young girl.



Bats
Bats(1999)
4.6

Genetically mutated bats escape and it's up to a bat expert and the local sheriff to stop them.



Python
Python(2000)
5.05

After a military plane crashes outside of a small American town, its cargo — a genetically engineered, sixty-foot-long python — begins stalking and killing the locals.



Breeder
Breeder(2020)
5.074

A renowned health supplement company, run by a ruthless businesswoman, is selecting and abducting young women as part of an experiment bio-hacking babies’ DNA to enable her clients to reverse the aging process. When Mia goes to investigate, she finds herself trapped, branded and tortured in a grim underground facility. Familiar faces start to appear, and she realises that she is not alone in this. Can she somehow find inner strength and escape from the nightmare?



Giant Spider
6.8

In a mysterious laboratory located in the desert, the experimental spiders used for genetic research mutate and turn into giant spider monsters, turning the laboratory into a giant spider's lair. A few days later, a special warfare team led by the captain Gao Qiang, escorting Dr. Chen, a scientist of the Kwon Plant Group, goes to the laboratory to rescue the trapped people and try to retrieve the relevant scientific research data



The Kindred
6

Amanda's deathbed request to her son, John, was for him to destroy all the lab notes etc. from her last experiment. She also blurts out he had a brother. At the funeral John meets Melissa, who claims to be his mother's biggest fan. Together with some of John's friends they go to Amanda's house, but none are prepared for what they find there.



Fixed
Fixed(2025)
6.239

After learning he's getting neutered, a dog has 24 hours to squeeze in one last balls-to-the-wall adventure with the boys.



Dog Gone
Dog Gone(2023)
6.217

When his beloved dog goes missing, a young man embarks on an incredible search with his parents to find him and give him life-saving medication.



The Blood Beast Terror

A scientist working with genetics creates a horrifying flying creature that feeds on human blood. Following a gruesome trail of dead bodies, Scotland Yard investigators must scramble to halt its ravenous rampage.



Good Boy
Good Boy(2022)
6.363

Christian, a millionaire heir, meets Sigrid, a young student, on a dating app. They hit it off quickly, but there's only one problem: Christian lives with Frank, a man who dresses up and constantly acts like a dog.



Higher Power
5.1

When the Universe decides what it wants, it's pointless to resist. With his family's life at stake, Joseph Steadman finds himself the unwilling test subject of a maniacal scientist in a battle that could save the world – or destroy it.



Baxter
Baxter(1989)
6.3

A white Bull Terrier named Baxter is given to an elderly woman by her daughter. As time passes, the dog develops aggressive and murderous behavior in order to be adopted by another family.



Tentacles
Tentacles(1977)
4.6

Several people disappear from and at the sea. Their bodies are found gnawed to the skeleton, even the marrow is missing. The scientists have no idea which animal could do such things. Dr. Turner begins to suspect that the company which builds a tunnel beneath the bay might have poisoned the environment and caused an octopus to mutate to giant dimensions...



Altered
Altered(2006)
5.426

Fifteen years ago, five men were abducted by aliens. Only four returned. Now, these same four men have managed to capture one of the creatures who killed their friend and ruined their lives.



The Cat o' Nine Tails

A newsman works with a blind puzzle-solver to uncover a deadly conspiracy linked to a genetic research facility.



Living Hell
5.241

In a top secret Cold War military project an unstoppable, malignant organism who feeds on light and energy is unleashed threatening to destroy everything in its path.



Rottweiler
3.4

Dante travels across a desolate, futuristic Spain in search of his girlfriend, Ula. He is pursued by a bloodthirsty, cybernetic Rottweiler.



Species III
5.2

After she delivers her child in an ambulance, alien Eve is killed by a half-breed. Fortunately, Dr. Abbot scoops up the baby alien and escapes. In time, the baby grows into a gorgeous blonde named Sara and begins her quest to find a worthy mate. But Sara is also savage and leaves a trail of deaths in her wake. This carnage makes chemistry student Dean question whether to help her race or not.



Isolation
Isolation(2005)
5.5

On a remote Irish farm, five people become unwilling participants in an experiment that goes nightmarishly wrong.



Tarantula
Tarantula(1955)
6.478

A rogue scientist near a small desert town arouses the suspicion of the town's doctor when his lab assistant is found dead from a case of acromegaly, which took only four days to develop. As the doctor investigates, aided by the scientist's new female assistant, they discover that something is devouring local cattle and humans in increasingly large quantities.



Breeders
Breeders(1986)
4.634

An otherwordly perpetrator has been attacking female virgins in Manhattan. As Dr. Pace and Detective Andriotti work together to identify the strange organic materials found on the women, the victims begin arising in a trance and leaving the hospital.



Monsters of Man
6.379

A robotics company vying to win a lucrative military contract team up with a corrupt CIA agent to conduct an illegal live field test. They deploy four weaponized prototype robots into a suspected drug manufacturing camp in the Golden Triangle, assuming they'd be killing drug runners that no one would miss. Six doctors on a humanitarian mission witness the brutal slaughter and become prime targets.



The Scientist
6

An unconventional scientist, struggling to care for his terminally-ill wife, embarks on a journey to develop a cure for her. However, his methods of treatment and tampering with human DNA, could lead to the extinction of humanity.



Robotropolis
3.1

A group of reporters are covering the unveiling of a new facility that is completely maintained by robot prototypes. When one of the robots goes haywire, the reporters find themselves not just reporting on the malfunction, but fighting for their lives.



The Island of Dr. Moreau

A plane crash surviving attorney stumbles upon a mysterious island and is shocked to discover that a brilliant scientist and his lab assistant have found a way to combine human and animal DNA—with horrific results.



Uninvited
Uninvited(1988)
4.753

A sinister corporation loses control of a house cat infected with a genetically-engineered virus. The death-toll rises during the mutant feline's rampage, and eventually, it finds its way on board a ship of a criminal king-pin.



Body Parts
5.8

A criminal psychologist loses his arm in a car crash, and becomes one of three patients to have their missing limbs replaced by those belonging to an executed serial killer. One of them dies violently, and disturbing occurrences start happening to the surviving two.



Mutation on Mars
6.7

In the near future, the Earth’s resources are gradually getting scarce. In order to continue the hope of survival for generations of children and grandchildren, top scientists from various countries have brought several species of animals and plants to Mars for research, hoping to improve the Martian environment through advanced science and technology to make it suitable for human habitation.



Critters 4
5

A super strain of genetically engineered mutants are designed to take over the universe, hungry to conquer the galaxy, with an appetite for mankind.



Growth
Growth(2010)
5.3

In 1989, a breakthrough in "advanced parasitic research" on Cuttyhunk Island gave scientists a jump in human evolution. Initial tests proved promising, as subjects experienced heightened physical and mental strength and awareness. But - something in the experiment went horribly wrong, and the island mysteriously lost three quarters of its population.



Die, Monster, Die!
5.6

A young man visits his fiancé's estate to discover that her wheelchair-bound scientist father has discovered a meteorite that emits mutating radiation rays that have turned the plants in his greenhouse to giants. When his own wife falls victim to this mysterious power, the old man takes it upon himself to destroy the glowing object with disastrous results.



The Terror Within
4.383

Experiments in biological warfare have destroyed all but a few remnants of the human race. Alone in a lab, eight students work feverishly to create a vaccine before they are forced outside in search for food. It is then that the surviving scientists discover creatures mutated by the plague. Now they prepare to do battle against their worst fear: The Terror Within.



The Black Hole
4.5

It's 2 A.M. in St. Louis when a routine scientific experiment goes terribly wrong and an explosion shakes the city. A scientific team investigates, clashing with an intergalactic, voltage-devouring creature that vaporizes them.



Finch
Finch(2021)
7.823

On a post-apocalyptic Earth, a robot, built to protect the life of his dying creator's beloved dog, learns about life, love, friendship, and what it means to be human.



Rampage
Rampage(2018)
6.456

Primatologist Davis Okoye shares an unshakable bond with George, the extraordinarily intelligent, silverback gorilla who has been in his care since birth. But a rogue genetic experiment gone awry mutates this gentle ape into a raging creature of enormous size. To make matters worse, it’s soon discovered there are other similarly altered animals. As these newly created alpha predators tear across North America, destroying everything in their path, Okoye teams with a discredited genetic engineer to secure an antidote, fighting his way through an ever-changing battlefield, not only to halt a global catastrophe but to save the fearsome creature that was once his friend.



Uncanny
Uncanny(2015)
5.932

For ten years, inventor David Kressen has lived in seclusion with his inventions, including Adam, a robot with incredible lifelike human qualities. When reporter Joy Andrews is given access to their unconventional facility, she is alternately repelled and attracted to the scientist and his creation. But as Adam exhibits emergent behavior of anger and jealousy towards her, she finds herself increasingly entangled in a web of deception where no one’s motives are easily decipherable.



Creature
Creature(1985)
4.6

A crew of scientists arrives on a far, cold planet to examine archaic artifacts of unknown origin. They discover that their German enemies already have a ship there. When they seek their help after a failed landing, they only find the Germans’ bodies, obviously slaughtered by one of the archaic creatures, awoken to new life. Now the alien is after them.



Deadly Friend
6.1

When tragedy strikes his remarkable robot and the beautiful girl next door, lonely teenage genius Paul tries to save them by pushing technology beyond its known limits into a terrifying new realm.



Black Sheep
5.778

After a childhood prank by his brother Angus causes Henry to develop a phobia of sheep, he must step up to the onslaught of a genetically-mutated man-eating flock with the help of his friend and a young environmentalist.



Underdog
Underdog(2007)
5.553

A lab accident gives a beagle named Shoeshine some serious superpowers -- a secret that the dog eventually shares with the young boy who becomes his owner and friend.



The Breed
The Breed(2001)
5.1

Vampires have come out of the shadows and are living as normal citizens. Two policemen, one a vampire, are assigned to track down a serial killer who tears the throat of his victims and drains their blood.



The Island of Dr. Moreau

A ship-wrecked man floats ashore on an island in the Pacific Ocean. The island is inhabited by a scientist, Dr. Moreau, who in an experiment has turned beasts into human beings.



Hulk
Hulk(2003)
5.575

Bruce Banner, a genetics researcher with a tragic past, suffers massive radiation exposure in his laboratory that causes him to transform into a raging green monster when he gets angry.



A Boy and His Dog
6.27

Set in the year 2024 in post-apocalyptic America, 18-year old Vic and his telepathic dog, Blood, are scavengers in the desolate wilderness ravaged by World War IV, where survivors must battle for food and shelter in the desert-like wasteland. Vic and Blood eke out a meager existence, foraging for food and fighting gangs of cutthroats.



The Titan
The Titan(2018)
5.3

On a bleak future Earth, a soldier endures a radical genetic transformation to save humanity. But his wife fears he's becoming more creature than man.



A-X-L
A-X-L(2018)
6.276

The life of a teenage boy is forever altered by a chance encounter with cutting edge military technology.



Antarctica
7.2

Two Japanese scientists, Ushioda and Ochi, develop a bond with their sled dogs while on an expedition in Antarctica.



Far Cry
Far Cry(2008)
3.7

Jack Carver, a former member of the Special Forces takes the journalist Valerie Cardinal to an Island to visit her uncle Max who is working in a Military complex on the Island. As they arrive Valerie gets captured by the minions of Doctor Krüger. After the destruction of his boat Jack finds out about the true purpose of the Facilities on the Island, which is the creation of genetic soldiers.



Vile
Vile(2011)
4.976

A group of people awaken to find themselves prisoners in a mysterious house with no means of escape. They are each outfitted with electronic devices attached to the base of their skulls. The chemicals that the brain produces when in pain are collected by the devices, and when it collects a predetermined amount, the doors will be opened. In order to escape, they must hurt themselves and each other.



Leviathan
Leviathan(1989)
6

Underwater deep-sea miners encounter a Soviet wreck and bring back a dangerous cargo to their base on the ocean floor with horrifying results. The crew of the mining base must fight to survive against a genetic mutation that hunts them down one by one.



Bolt
Bolt(2008)
6.5

Bolt is the star of the biggest show in Hollywood. The only problem is, he thinks it's real. After he's accidentally shipped to New York City and separated from Penny, his beloved co-star and owner, Bolt must harness all his "super powers" to find a way home.



Tau
Tau(2018)
6.165

Held captive in a futuristic smart house, a woman hopes to escape by befriending the A.I. program that controls the house.



Bad Moon
Bad Moon(1996)
6.7

One man's struggle to contain the curse he hides within... and his last-ditch attempt to free himself with the love of family. But when it looks as if he is losing his battle, and endangering all he holds most dear, the family dog, Thor, is the last hope for his family's survival... and the end to his Werewolf curse.



Bad Biology
4.5

Driven by biological excess, a young man and woman search for sexual fulfillment, unaware of each other's existence. Unfortunately, they eventually meet, and the bonding of these two very unusual human beings ends in an explosive and ultimately over-the-top sexual experience, resulting in a truly god awful love story....



Adam and Dog
6.6

The story about the dog of Eden. What happened in those first days of Creation that made Man and Dog so inseparable? The dog, as he lives through this curious world, encounters a strange creature; a human being named Adam - and with that discovers a new found connection to the world.



Good Boy!
Good Boy!(2003)
5.5

An intergalactic dog pilot from Sirius (the dog star), visits Earth to verify the rumors that dogs have failed to take over the planet.



Project X
Project X(1987)
6.3

A young inductee into the military is given the task of looking after some chimpanzees used in the mysterious 'Project X'. Getting to know the chimps fairly well, he begins to suspect there is more to the secret project than he is being told.



Dangerous Animals
6.4

A savvy and free-spirited surfer is abducted by a shark-obsessed serial killer. Held captive on his boat, she must figure out how to escape before he carries out a ritualistic feeding to the sharks below.



Frankenweenie
6.93

When young Victor's pet dog Sparky (who stars in Victor's home-made monster movies) is hit by a car, Victor decides to bring him back to life the only way he knows how. But when the bolt-necked "monster" wreaks havoc and terror in the hearts of Victor's neighbors, he has to convince them (and his parents) that despite his appearance, Sparky's still the good loyal friend he's always been.



Blood Glacier
5.734

At a climate research station in the Alps, the scientists are stunned as the nearby melting glacier is leaking a red liquid. It quickly turns to be very special juice — with unexpected genetic effects on the local wildlife.



Puppy Love
6.992

After a disastrous first date, wild-child Nicole and socially-anxious Max vow to lose each other’s numbers until they learn that their dogs found a love match, and now puppies are on the way! The hilariously mismatched Nicole and Max are forced to become responsible co-parents, but may end up finding love themselves.



Spiders II: Breeding Ground

Happy couple Jason and Alexandra lose their sail yacht in a storm and are grateful to get picked up by Captain Jim Bigelow's commercial carrier. Suspicious about the ship's doctor and realizing the ship is improbably empty and the radio not broken as the crew claims, Jason starts snooping around. Bodies on meat-hooks, genetic experimentation and giant spiders are what he finds.



The Killer Shrews
4.417

Trapped on a remote island by a hurricane, a group discover a doctor has been experimenting on creating half sized humans. Unfortunately, his experiments have also created giant shrews, who when they have run out of small animals to eat, turn on the humans.



Humane
Humane(2024)
5.422

In the wake of an environmental collapse that has forced humanity to shed 20% of its population, a family dinner erupts into chaos when a father's plan to enlist in the government's new euthanasia program goes horribly awry.



Good Boy
Good Boy(2025)
6.8

A loyal dog moves to a rural family home with his owner Todd, only to discover supernatural forces lurking in the shadows. As dark entities threaten his human companion, the brave pup must fight to protect the one he loves most.



Carnosaur
Carnosaur(1993)
4.2

After being driven to extinction, great bloodthirsty dinosaurs come back to life with the assistance of a demented genetic scientist. She plans to replace the human race with a super-race of dinosaurs who will not pollute the planet.



Errors of the Human Body

Canadian scientist, Dr Geoff Burton takes up a position at a new institute in wintry Dresden in order to contribute to their most important project—a human regeneration gene—that also has the potential to make something miraculous out of a personal tragedy that has haunted him for years.



Deep Blue Sea
6

Researchers on the undersea lab Aquatica have genetically altered the brains of captive sharks to develop a cure for Alzheimer's disease. But there's an unexpected side effect: the sharks got smarter, faster, and more dangerous. After a big storm damages their remote research facility, they must fight for their lives.



Species: The Awakening

A scientist, Dr Hollander, takes his niece Miranda to Mexico in an attempt to reverse the effects of the alien DNA he used to create her. However the treatment goes horribly wrong, and sets Miranda on a killing spree as she sets out to find a mate.



Cats & Dogs
5.4

When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.



The Lawnmower Man
5.6

A simple man is turned into a genius through the application of computer science.



Night of the Lepus
4.41

Rancher Cole Hillman is fed up of rabbits plaguing his fields. Zoologist Roy Bennett conducts an experiment to curb their population, but it gives rise to giant rabbits that terrorise the town.



Supernova
Supernova(2000)
4.946

Set in the 22nd century, when a battered salvage ship sends out a distress signal, the seasoned crew of the rescue hospital ship Nova-17 responds. What they find is a black hole--that threatens to destroy both ships--and a mysterious survivor whose body quickly mutates into a monstrous and deadly form.



Michael
Michael(1996)
5.7

Tabloid reporters are sent by their editor to investigate after the paper recieves a letter from a woman claiming an angel is living with her.



Cujo
Cujo(1983)
6.1

A friendly St. Bernard named "Cujo" contracts rabies and conducts a reign of terror on a small American town.



Monster on the Campus
6.038

A college paleontology professor acquires a newly discovered specimen of a coelacanth, but while examining it, he is accidentally exposed to its blood, and finds himself periodically turning into a murderous Neanderthal man.



Companion
Companion(2025)
7

During a weekend getaway at a secluded lakeside estate, a group of friends finds themselves entangled in a web of secrets, deception, and advanced technology. As tensions rise and loyalties are tested, they uncover unsettling truths about themselves and the world around them.



Listening
Listening(2015)
5.7

For years, we have tried to harness the power of the human mind… and failed. Now, one breakthrough will change everything. Beyond technology. Beyond humanity. Beyond control. David, Ryan, and Jordan hope the telepathy invention will solve all their problems, but the bleeding-edge technology opens a Pandora’s box of new dangers, as the team discovers that when they open their minds, there is nowhere to hide their thoughts.



Triassic Hunt
5.3

When two genetically created dinosaurs end up on the loose, it's up to a team of rag tag mercenaries to capture them. When the realize that the dinosaurs are bred as smart as humans, the game of cat and mouse turns for the worst.



A Dog's Way Home
7.4

The adventure of Bella, a dog who embarks on an epic 400-mile journey home after she is separated from her beloved human.



The Pack
The Pack(2015)
5.715

Man’s best friend becomes his worst nightmare when a horde of bloodthirsty wild dogs descends upon a family’s farmhouse in a fang-bearing fight for survival.



Werewolves
5.928

A year after a supermoon’s light activated a dormant gene, transforming humans into bloodthirsty werewolves and causing nearly a billion deaths, the nightmare resurfaces as the supermoon rises again. Two scientists attempt to stop the mutation but fail and must now struggle to reach one of their family homes.



Megan Leavey
7.274

The true story of Marine Corporal Megan Leavey, who forms a powerful bond with an aggressive combat dog, Rex. While deployed in Iraq, the two complete more than 100 missions and save countless lives, until an IED explosion puts their faithfulness to the test.



Arachnid
Arachnid(2001)
4.247

Mercer's brother, an amateur pilot, crashes on an island and is killed by a giant spider. A year later, when Mercer goes in search of him, she discovers a breed of poisonous arachnids ready to attack.



Man Trouble
4.9

A sleazy but affable guard dog trainer is blackmailed to steal a manuscript for a tell-all book from one of his clients.



Killers
Killers(2014)
6.5

A psychotic executive triggers a journalist's dark side, and they begin to form a strange bond through the internet.

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