Molly McKay is a profoundly autistic twenty-something woman who has lived in an institution from a young age following her parents' death in a car accident. When the institution must close due to budget cuts, Molly is left in the care of her neurotypical, older brother, Buck McKay, an advertising executive and perennial bachelor. Buck forces her to undergo an experimental medical treatment, with unexpectedly drastic results.

Irene lives in Rome. When her mother ask to, she go back to Rimini, her hometown, to take care of her autistic brother, Omar. She soon discover that Omar knows very well what to expect from the future, but in order to achieve his dreams, he need to be independent, which is why Irene begins a tender crash course to teach him adult life.

Sam and Gray are such a well-matched pair that it is difficult to believe they are brother and sister rather than husband and wife. They both share a love of 1940s movies and dancing, and when they meet Charlie, they have something else in common: They both fall in love with her. Sam must deal with unexpected feelings of jealousy, while Gray struggles to come to terms with her sexual orientation.

The story of Bea Johnson from birth to graduation as she navigates life with an intellectually disabled parent and an extended family who can't quite agree on the best way to help.

Laura, 21, is determined to earn her High school diploma, just like anyone else. Except Laura is a bit different. She has Down syndrome. As she faces her own difficulties, she must also deal with the doubts of her loved ones and the occasional cruelty of her peers. Overcoming challenge after challenge between emotion and laughter, Laura battles for every inch of an opportunity that life tries to keep from her. Like a movie in which disability brings a fresh perspective on life challenges and the pursuit of happiness.

After returning to her childhood home, young nun Colleen finds her old room exactly how she left it: painted black and covered in goth and metal posters. Her parents are happy enough to see her, but her brother is living as a recluse in the guesthouse since returning home from the Iraq war.

An intimate family portrait of four hapless but resilient women and the bittersweet lessons they learn in keeping up with the hectic demands of their individual neuroses. Each of the women seeks redemption in her own haphazard way, but whatever salvation they find is illusory and short-lived.

Zu, a free spirit estranged from her family, suddenly finds herself the sole guardian of her half-sister, Music, a teenager on the autism spectrum whose whole world order has been beautifully crafted by her late grandmother. The film soon challenges whether it is Zu or Music who has a better view of the world, and that love, trust, and being able to be there for each other is everything.

A mentally ill young woman finds her love in an eccentric man who models himself after Buster Keaton.

A drama set at a Swiss ski resort and centered on a boy who supports his sister by stealing from wealthy guests.

A leukemia patient attempts to end a 20-year feud with her sister to get her bone marrow.

An adventurous love story between two young women of different social and economic backgrounds who find themselves going through all the typical struggles of a new romance.

After the death of their estranged father, 3 adult sisters invite their teenaged half-sister to live with them.

Halley is convinced true love doesn't exist based on the crazy relationships around her. Her mother is divorcing her father who is dating a younger woman Halley can't stand. Her crazed sister is planning a wedding but has second thoughts and her best friend has fallen madly in love for the first time leaving Halley to feel even more alone.

Everybody has one—the sibling who is always just a little bit behind the curve when it comes to getting his life together. For sisters Liz, Miranda and Natalie, that person is their perennially upbeat brother, Ned. But as each of their lives begins to unravel, Ned's family comes to realise that Ned isn't such an idiot after all.

Teenager David Clemens develops a hysterical fear that he will die if he comes into physical contact with another person. Perturbed, David's overbearing mother places him in a home for mentally disturbed young people, but David remains withdrawn from the other patients and his psychiatrist. Over time, however, David grows interested in 15-year-old Lisa, who suffers from multiple personalities – one who can only speak in rhyme, and the other, a mute.

Follows the life of a young woman who has become reserved and indifferent to the world as a result of her chronic illness deformed hand and quietly portrays the unconventional, yet endearing relationship between mother and daughter as well as the development of Min-ah as she is befriended by the high spirited and carefree photographer Young-jae who moves into their apartment complex.

Teenager Cleo's school science project goes quite awry, causing her popular older sister Molly to go invisible.

Four sisters come of age in America in the aftermath of the Civil War.

Hal is a 15-year-old high-school student with a minor yet socially alienating (and painful) disability: he stutters uncontrollably. Determined to work through the problem, Hal opts for an extreme route – he joins the school debating team, which sends him on a headfirst plunge into breakneck speech competitions and offers a much-needed boost toward correcting the problem.

Daisy and Viola are siamese twin sisters on the verge of turning 18 living in the suburbs of Naples. They are blessed with beautiful voices and thanks to their performances at weddings, communions and baptisms, they get the livelihood for the whole family. Kept isolated from the rest of the world by their own father who just exploits them in order to make money, their life turns upside-down when one of them falls in love for the first time and they discover that they can be separated.

A reporter witnesses a brutal murder and becomes entangled in a mystery involving a pair of twins.

When their father's will forces them to live together, siblings Nik and Tesla — and Tesla's kids — try to overcome their differences to become a family.

Two sisters find their already strained relationship challenged as a mysterious new planet threatens to collide with Earth.

After graduating from film school, Aura returns to New York to live with her photographer mother, Siri, and her sister, Nadine, who has just finished high school. Aura is directionless and wonders where to go next in her career and her life. She takes a job in a restaurant and tries unsuccessfully to develop relationships with men, including Keith, a chef where she works, and cult Internet star Jed.

A rebellious young woman with cerebral palsy leaves India to study in New York. On her journey of self-discovery, she unexpectedly falls in love.

Two disconnected sisters are summoned to clean out their childhood bedrooms before their parents sell their family home.

When her idolized twin sister Audrey dies in a car accident, Laurel decides to take her place. But, as she eases into the life she has always wanted, she must decide between continuing the lie or revealing herself.

After experiencing a traumatic misfortune, Jasmine French, a wealthy woman from New York, moves to San Francisco to live with her foster sister Ginger and the firm purpose of getting a new life, but she will be haunted by anxiety and memories of the past.

Four young women continue the journey toward adulthood that began with "The Sisterhood of the Traveling Pants." Now three years later, these lifelong friends embark on separate paths for their first year of college and the summer beyond, but remain in touch by sharing their experiences with each other.

In this modern adaptation of Jane Austen’s Sense and Sensibility, Elinor and Marianne find themselves penniless after their father’s fortune is taken away. As they look for ways to pay the bills, they encounter people who judge them and try to keep them down in the dumps. Add falling in love into the mix, and determining whom to trust becomes a mine field. Can the sisters find a balance between relying on their hearts and using good sense without losing everything they hold dear?

After the death of her mother, a woman returns home to care for her sister.

Christopher is an ambitious college freshman, striving to become a writer. Through a computer fault he's assigned the same room as Alex, a real party freak and... a girl! He's annoyed and tries to get a different room as soon as possible, but when he learns to know her, he also starts to like her. She not only improves his sexual life, but also his writing skills

A young woman who has been in and out from rehab for the past 10 years returns home for the weekend for her sister's wedding.

Clara and Diego, under the guidance of the psychiatrist of a day rehabilitation center for disturbed people who attend, decide to transform the treatment center into a restaurant, involving all their other companions.

When Eve, an interior designer, is deserted by her husband of many years, Arthur, the emotionally glacial relationships of the three grown-up daughters are laid bare. Twisted by jealousy, insecurity and resentment, Renata, a successful writer; Joey, a woman crippled by indecision; and Flyn, a budding actress; struggle to communicate for the sake of their shattered mother. But when their father unexpectedly falls for another woman, his decision to remarry sets in motion a terrible twist of fate…

Three sisters - Georgia, Eve, and Maddy - do what they do best with life, love, and lunacy on the telephone lines that bind - when their curmudgeonly father, Lou, is admitted to a Los Angeles Hospital. After years of wild living, intermittent affection, and constant phoning, he is finally threatening to die.

In the wake of a school tragedy, Vada, Mia and Quinton form a unique and dynamic bond as they navigate the never linear, often confusing journey to heal in a world that feels forever changed.

Just as Stella enters the exciting world of adolescence she discovers that her big sister and role model Katja is hiding an eating disorder. The disease slowly tears the family apart. A story about jealousy, love and betrayal told with warmth, depth and laughter - on and off the ice.

With their father away as a chaplain in the Civil War, Jo, Meg, Beth and Amy grow up with their mother in somewhat reduced circumstances. They are a close family who inevitably have their squabbles and tragedies. But the bond holds even when, later, male friends start to become a part of the household.

David, a struggling comedy writer fresh off from breaking up with his boyfriend, moves from New York City to Sacramento to help his sick mother. Living with his conservative father and much-younger sisters for the first time in ten years, he feels like a stranger in his childhood home. As his mother’s health declines, David frantically tries to extract meaning from this horrible experience and convince everyone (including himself) that he's "doing okay.”

A decades-spanning tale of love and resilience and of one woman's journey to independence. Celie faces many hardships in her life, but ultimately finds extraordinary strength and hope in the unbreakable bonds of sisterhood.

Precocious young Harriet and her older sister Gwen live at their mother's motel in small-town New Hampshire. Harriet dreams of a life beyond her inattentive family and the stultifying town. A mentally disabled man named Ricky comes to stay at the motel, and Harriet finds him kinder and more interesting than anyone she has ever met. After tragedy strikes, Harriet and Ricky cling to each other ever more tightly.

On the outside, Helen has it all – a loving family and a successful career – but when her suppressed mental illness resurfaces, the world crumbles around her. Crippled by depression, Helen finds solace through her friendship with Mathilda, a kindred spirit struggling with bipolar disorder.

Shy, straight-A student Ellie is hired by sweet but inarticulate jock Paul, who needs help wooing the most popular girl in school. But their new and unlikely friendship gets tricky when Ellie discovers she has feelings for the same girl.

After a breakup with her boyfriend, a young woman moves in with her older brother, his wife, and their 2-year-old son.

A dramatic comedy about a self-induced attention-deficit disordered, learning disabled, Tourette's syndrome suffering, balance impaired, ex-alcoholic young man from the Upper East Side of Manhattan and the gold-digging girl who inspires him to try to get it together.

A charming romance develops between a boy with one eye and an overweight girl, though when she loses weight after going to college, their relationship is tested in devastating ways they never dreamed would happen.

A younger sister wishes to switch places with her popular older sister and the two bickering siblings awaken to find the wish has come true.

On a university scholarship, a good natured student from the midwest gets a crash course in city life while dealing with three evil roommates. He befriends a virtually homeless college student whom he falls for, but she's dating a nasty professor.

When Will Browning is threatened with military summer school if he doesn't get better grades, he decides to do a science project that will definitely get an A. So he buys some Ocean Pups, unhatched sea creatures that will look spectacular, but he hasn't bargained for the cloning agent that the unscrupulous manufacturers have put in the kit. Next thing he knows there's another him.

Still mourning the death of her mother a few years back, Alice McKinley finds her life seriously disrupted when her father Ben buys a store and moves her and her older brother Lester to a new town.

Yuma, a 23-year-old comic book artist with profound cerebral palsy, has been emotionally stunted by her well-meaning but overprotective mother. As she begins to seek independence and sexual awakening on her own terms, she discovers an unexpected path to love and forgiveness.

Medical-school dropout Wallace has been repeatedly burned by bad relationships. So while everyone around him, including his roommate Allan, seems to be finding the perfect partner, Wallace decides to put his love life on hold. It is then that he meets Chantry, an animator who lives with her longtime boyfriend Ben. Wallace and Chantry form an instant connection, striking up a close friendship. Still, there is no denying the chemistry between them, leading the pair to wonder, what if the love of your life is actually your best friend?

Years after Tess and Anna endured an identity crisis, Anna now has a daughter of her own and a soon-to-be stepdaughter. As they navigate the myriad challenges that come when two families merge, Tess and Anna discover lightning might indeed strike twice.

A young woman escapes her wildly eccentric family in search for a life of normalcy.

Not long after moving into her own place, Maggie finds herself with two unsolicited roommates: her recently divorced mother, Lila, and her young brother. The timing is especially bad, considering Maggie has fallen hard for an attractive woman, Kim, only hours before they move in. What could be a nonissue becomes increasingly complicated -- since Maggie's family is unaware of her sexual orientation, and Maggie is not open to sharing that information.

Highly intelligent computer major Zoey Miller is uninterested in romantic love, but her life is turned upside down when Zack, the school's soccer star, gets amnesia and mistakes Zoey for his girlfriend.

Melody Brooks, a sixth grader with cerebral palsy, has a quick wit and a sharp mind, but because she is non-verbal and uses a wheelchair, she is not given the same opportunities as her classmates. When a young educator notices her student's untapped potential and Melody starts to participate in mainstream education, Melody shows that what she has to say is more important than how she says it.

Alice and Louis are brother and sister. She is an actress; he was a teacher and poet. For more than 20 years, Alice has hated her brother. In all this time they haven’t seen one another. The death of their parents brings the siblings face to face.

This comedy takes its cue from such female-centered films as "Bridesmaids" and "Trainwreck." Pic centers on a woman who makes a living from breaking up couples and decides to take on the task of splitting up her sister's relationship with her jerk of a boyfriend.

Growing up in the sheltered confines of a 1920s English coal-mining community, free-spirited sisters Gudrun and Ursula explore erotic love with a wealthy playboy and a philosophical educator, with cataclysmic results for all four.

After breaking up with her boyfriend, a bookstore manager resists a seemingly perfect guy's attempts to woo her.

Jessica Darling – a smart, witty, opinionated girl heading into 7th grade – was never too concerned about where she'd fit in the middle school hierarchy. But before her first day of school, her older sister — the super popular Bethany, now in college—decides to help out by giving her the “It List”—a cheat sheet on how to navigate the middle school maze and rise to the top of the popularity chain. The instructions appear simple enough to follow, but, like life, nothing is as easy as it seems.

Follows the fate of Lyle, a violent adolescent who, in lieu of prison, is placed in a juvenile mental institution, where he encounters a group of equally troubled teens. This motley crew—abused, sexually confused, violent, and yet hanging on by their grit and anger—becomes Lyle's last lifeline as he fights to find meaning in a world that seems to defy understanding.

A teenage girl gets diagnosed with a reproductive condition that upends her plans to have sex and propels her into exploring unusual methods to have a sex life, challenging her relationships with everyone in her life, but most importantly, herself.

As single mom Grace juggles work, bills, and her affair with a married doctor, her daughter, Ansiedad, plots a shortcut to adulthood after finding inspiration in the coming-of-age stories she's reading for school.

Emilia, a law-school graduate, falls in love with her married boss, Jack. After Emilia marries Jack, her happiness turns unexpectedly to grief following the death of her infant daughter. Devastated, Emilia nonetheless carries on, attempting to forge a connection with her stepson William and to resist the interference of Jack's jealous ex-wife.

Two spoiled Beverly Hills sisters who have been left penniless after their father's sudden death are forced to move in with their estranged aunt in East Los Angeles.

A mother and her daughter confront the intimidation of teen peer pressure and the emotionally brutalizing social rituals of high school.

Routinely exploited by her wicked stepmother, the downtrodden Samantha Montgomery is excited about the prospect of meeting her Internet beau at the school's Halloween dance.

Ramona is a little girl with a very big imagination and a nose for mischief. Her playful antics keep everyone in her loving family on their toes, including her older sister Beezus, who's just trying to survive her first year of high school. Through all the ups and downs of childhood, Ramona and Beezus learn that anything's possible when you believe in yourself and rely on each other.

After serving five years in prison, wild child Tanya looks to her buttoned-up, by-the-book sister Danica to help her get back on her feet. The feisty ex-con becomes suspicious and concerned when Danica tells her that she's in a long-distance, online relationship with a mysterious man she's never seen. As the polar opposites start to collide, Tanya soon discovers that her sibling's picture-perfect life may not be what it seems.

Marjorie Turner is suffocating in her marriage and day to day life. An extramarital affair with a stranger seems to be the answer until her paramour has a fatal heart attack, and turns out to be less of a stranger than she could have thought...

Helen Harris has a glamorous, big-city life working for one of New York's hottest modeling agencies. But suddenly her free-spirited life gets turned upside down when she must chose between the life she's always loved, and the new loves of her life!

Mourning his brother's recent death, Pierrick accepts his best friend Tessa's invitation to stay in her family home — at last, a week alone. But when her gets there, he finds the house already occupied by Tessa's sister Marie.

Four best friends (Tibby, Lena, Carmen & Bridget) who buy a mysterious pair of pants that fits each of them, despite their differing sizes, and makes whoever wears them feel fabulous. When faced with the prospect of spending their first summer apart, the pals decide they'll swap the pants so that each girl in turn can enjoy the magic.

A college student starts to experience extreme seizures. She soon learns that the violent episodes are a symptom of inexplicable abilities.

Lena is a bright, disabled girl who, after years spent studying at home, is keen to get back to school. She is assigned to a special class for disabled pupils who have to present themselves before a school commission at the end of the year in order to prove that they merit being moved back into a "normal" class. Her enervated teachers, however, show absolutely no desire to motivate the students and help them improve; on the contrary, they try to quash right from the start any interest Lena shows in more complex study material. Nevertheless, Lena soon involves herself in the school routine and gets together with classmate Anton. Yet their transparent happiness is not to everyone's liking and repercussions soon follow.

Lennie is a teen musical prodigy grieving the death of her sister when she finds herself caught between a new guy at school and her sister's devastated boyfriend. Through her vivid imagination and conflicted heart, Lennie navigates first love and first loss.

Simon has Asperger's syndrome and doesn't like changes in his life. He lives with his big brother Sam and Sam's girlfriend Frida. When Frida can't stand having to adapt to Simon's peculiarities anymore she takes off, leaving Simon with having to find a new, perfect, girlfriend for his brother.

Three sisters try to come to grips with the meaning of their mother's suicide.

After getting into a car accident while drunk on the day of her sister's wedding, Gwen Cummings is given a choice between prison or a rehab center. She chooses rehab, but is extremely resistant to taking part in any of the treatment programs they have to offer, refusing to admit that she has an alcohol addiction.

When Jane is rejected by life, she spirals into a chaotic, schizophrenic world where love and normality collide with humorous consequences.

After several years of living with a cult, Martha finally escapes and calls her estranged sister, Lucy, for help. Martha finds herself at the quiet Connecticut home Lucy shares with her new husband, Ted, but the memories of what she experienced in the cult make peace hard to find. As flashbacks continue to torment her, Martha fails to shake a terrible sense of dread, especially in regard to the cult's manipulative leader.

Handsome but backward gardener Tim Melville has a new woman in his life. She is Mary, his widowed employer, a woman who had given up on love until she had found Tim. At first they are friends. But soon they become lovers, as Mary, drawn to Tim's innocence and magnetism, begins to teach him all about life - and love.

When her husband suddenly dumps her, longtime dedicated housewife Deanna turns regret into re-set by going back to college... landing in the same class and school as her daughter, who's not entirely sold on the idea. Plunging headlong into the campus experience, the increasingly outspoken Deanna – now Dee Rock – embraces freedom, fun, and frat boys on her own terms, finding her true self in a senior year no one ever expected.

A movie about two sisters - thirteen year old Sveta, poor and abandoned by her father, who longs to go off and be a sniper in the army, and spoilt eight-year old Dina, doted on by her gangster father...

Sally and Gillian Owens, born into a magical family, have mostly avoided witchcraft themselves. But when Gillian's vicious boyfriend, Jimmy Angelov, dies unexpectedly, the Owens sisters give themselves a crash course in hard magic. With policeman Gary Hallet growing suspicious, the girls struggle to resurrect Angelov -- and unwittingly inject his corpse with an evil spirit that threatens to end their family line.

Cal Weaver is living the American dream. He has a good job, a beautiful house, great children and a beautiful wife, named Emily. Cal's seemingly perfect life unravels, however, when he learns that Emily has been unfaithful and wants a divorce. Over 40 and suddenly single, Cal is adrift in the fickle world of dating. Enter, Jacob Palmer, a self-styled player who takes Cal under his wing and teaches him how to be a hit with the ladies.

While on Christmas break, college student Michael journeys to Quebec City to spend time with his attractive girlfriend, Gabriella. Not long after he arrives, Gabriella breaks up with him, but her two equally gorgeous sisters waste no time showing romantic interest. In the meantime, Michael is left to deal with Gabriella's eccentric grandmother and offbeat father, an academic who spends most of his time naked.

A lady has her prim and proper life turned upside down after discovering her husband's affair.

Lauren, a lovely 29-year-old it-girl, tries to break into the world of fashion by skimming Parisian parties. Olivia, a 28-year-old psychologist, has two obsessions: to save the confectionery of her parents, and to find her ideal husband. At the age of 26, Salma, a fiery young history teacher, still lives with her mother in the suburbs. Their roads have no reason to cross - until the day when, on the death of their biological father that they never knew, they inherit together a splendid Parisian apartment. For these three sisters who have nothing in common, cohabitation will prove to be explosive, to say the least.

Punk-rocker turned suburban mom, Kelly, is nostalgic for a life she can no longer have and uncertain of a future she doesn’t yet fit in. Seventeen-year-old Cal is frustrated at his lack of control over the hand he's been dealt. When the two strike up an unlikely friendship, it's the perfect spark needed to thrust them both back to life.

Ryan and Jennifer are opposites who definitely do not attract. At least that's what they always believed. When they met as twelve-year-olds, they disliked one another. When they met again as teenagers, they loathed each other. But when they meet in college, the uptight Ryan and the free-spirited Jennifer find that their differences bind them together and a rare friendship develops.

Two co-workers, one a vain woman and the other an awkward teenager, share an increasingly bizarre relationship after becoming roommates.

Frank, a single man raising his child prodigy niece Mary, is drawn into a custody battle with his mother.

Altruistic Jane finds herself facing her worst nightmare as her younger sister announces her engagement to the man Jane secretly adores.

Top student Jane Ryan heads to Manhattan for a college-scholarship competition. Her rebellious twin Roxy Ryan goes along to crash a video shoot. But anything can happen - and does - in a romp involving a pursuing truant officer, a smuggler, hunkalicious guys and the girls' realization that when the chips are down, a sister can be the best friend of all.