A dysfunctional couple head to a remote lakeside cabin under the guise of reconnecting, but each has secret designs to kill the other. Before they can carry out their respective plans, unexpected visitors arrive and the couple is faced with a greater danger than anything they could have plotted.

When Steve Coogan is asked by The Observer to tour the country's finest restaurants, he envisions it as the perfect getaway with his beautiful girlfriend. But, when she backs out on him, he has no one to accompany him but his best friend and source of eternal aggravation, Rob Brydon.

Unable to cope with a recent personal tragedy, LA's top celebrity shrink turns into a pothead with no concern for his appearance and a creeping sense of his inability to help his patients.

Robert Dupea spends his days doing various odd jobs, drinking and womanizing until an encounter with his sister makes him revisit his past.

Wyatt and Billy, two Harley-riding hippies, complete a drug deal in Southern California and decide to travel cross-country in search of spiritual truth.

A man on the verge of a promotion takes a mysterious hallucinogenic drug that begins to tear down his reality and expose his life for what it really is.

After a shallow womanizer refuses a mysterious homeless woman's request for a kiss, he wakes up the next morning to discover he's been changed into a woman.

Paul Rivers, an ailing mathematician lovelessly married to an English émigré; Christina Peck, an upper-middle-class suburban housewife and mother of two girls; and Jack Jordan, a born-again ex-con, are brought together by a terrible accident that changes their lives.

A young man turns from drug addiction and petty crime to a life redeemed by a discovery of compassion.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

Celebrities recall their most mind-bending trips via animations, reenactments and more in this comedic documentary exploring the story of psychedelics.

After getting into a serious car accident, a TV director discovers an underground sub-culture of scarred, omnisexual car-crash victims, and he begins to use car accidents and the raw sexual energy they produce to try to rejuvenate his sex life with his wife.

A New York film director, working on his latest movie in Los Angeles, begins to reflect the actions in his movie and real life, especially when he begins an affair with the lead actress.

Two drifters bum around, visit earthy women and discuss opening a car wash in Pittsburgh.

Twenty-something Richard travels to Thailand and finds himself in possession of a strange map. Rumours state that it leads to a solitary beach paradise, a tropical bliss - excited and intrigued, he sets out to find it.

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Lenny Brown moves to California to find his fortune in tax shelter investments. When the federal government changes the tax laws, poor Lenny finds himself $700,000 in hock with nowhere to turn. His friend, Joel, introduces him to cocaine to give Lenny that needed "boost". What ensues next is a descent into drug addiction and insanity as Lenny tries to regain control of his life, all the while needing that extra "boost".

A recovering drug addict is granted a day’s leave from rehab and returns to Oslo, where he reconnects with friends, faces the weight of his past, and struggles with uncertainty about his future. Over the course of one day, he drifts through encounters that reflect his longing for connection and his deep sense of alienation.

Rock-and-roll singer Mary Rose Foster's romantic relationships and mental health are continuously imperilled by the demands of life on the road.

Commercial airline pilot Whip Whitaker has a problem with drugs and alcohol, though so far he's managed to complete his flights safely. His luck runs out when a disastrous mechanical malfunction sends his plane hurtling toward the ground. Whip pulls off a miraculous crash-landing that results in only six lives lost. Shaken to the core, Whip vows to get sober -- but when the crash investigation exposes his addiction, he finds himself in an even worse situation.

In downtown Manhattan, twentysomething Allie, whose father is not around and whose mother is institutionalized, is a big Charlie Parker fan. He almost subconsciously searches for meaning in his life and meets some idiosyncratic characters along the way.

In the near future, due to a breakthrough scientific discovery by Dr. Thomas Harbor, there is now definitive proof of an afterlife. While countless people have chosen suicide to reset their existence, others try to decide what it all means. Among them is Dr. Harbor's son Will, who has arrived at his father's isolated compound with a mysterious young woman named Isla. There, they discover the strange acolytes who help Dr. Harbor with his experiments.

A vampiric doctoral student tries to follow the philosophy of a nocturnal comrade and control her thirst for blood.

A young woman left her family for an unspecified reason. The husband determines to find out the truth and starts following his wife. At first, he suspects that a man is involved. But gradually, he finds out more and more strange behaviors and bizarre incidents that indicate something more than a possessed love affair.

Following a breakdown and suicide attempt, an aging actor becomes involved with a much younger woman but soon finds that it's difficult to keep pace with her.

A weekend getaway for four couples takes a sharp turn when one of the couples discovers the entire trip was orchestrated to host an intervention on their marriage.

The son of a wealthy businessman finds solace in drugs and alcohol when he breaks up with his childhood love.

A poet falls in love with an art student, who gravitates to his bohemian lifestyle — and his love of heroin. Hooked as much on one another as they are on the drug, their relationship alternates between states of oblivion, self-destruction, and despair.

Faced with the decision of a lifetime, Arvilla Holden enlists her two best friends and sets off in a vintage '66 Bonneville convertible to deliver her late husband's ashes to Santa Barbara.

An adman attempts to rebuild his shattered life after suffering a nervous breakdown.

A German student, Stefan, now finished with his studies, hitchhikes to Paris. There he meets a free-spirited American girl, Estelle, who he follows to Ibiza. The two begin a sad and dark path into heroin addiction.

After a film production wraps in Peru, an American wrangler decides to stay behind, witnessing how filmmaking affects the locals.

A teenager stops off to see his dealer to test a new drug before heading off for a night of partying. On the way home, he picks up an injured woman, and the night takes a surreal turn.

A group of friends on holiday on an island experiment with a new designer drug that makes them lose their ability to control their urges.

A common friend's sudden death brings three men, married with children, to reconsider their lives and ultimately leave the country together. But mindless enthusiasm for regained freedom will be short-lived.

Theresa, a haunted young woman spiraling in the wake of profound loss, is torn between her fractured emotional state and the reality-altering effects of a potent cannabinoid drug.

The life of a woman is transformed after she is diagnosed with a terminal disease, fired from her job and abandoned by her boyfriend. Given two months to live, she throws caution to the wind to pursue her dreams.

Single mom Laura, along with her awkward 14 year-old son Henry is forced to drive Jack, her estranged, care-free pot dealing father across country after he's kicked out of yet another nursing home.

An alcoholic drifter spends Halloween in his hometown of Albany, New York after returning there for the first time in decades.

In need of creative inspiration, a professionally stagnant and hard-partying Los Angeles artist recklessly indulges in a series of drug binges. As the narcotics fly out of control, so does her newfound and inexplicable, yet unquenchable, craving for blood.

When a housewife finds out she is pregnant, she runs out of town looking for freedom to reevaluate her life decisions.

Two couples on an oceanside getaway grow suspicious that the host of their seemingly perfect rental house may be spying on them. Before long, what should have been a celebratory weekend trip turns into something far more sinister.

Carrie Watts is living the twilight of her life trapped in an apartment in 1940s Houston, Texas with a controlling daughter-in-law and a hen-pecked son. Her fondest wish – just once before she dies – is to revisit Bountiful, the small Texas town of her youth which she still refers to as "home."

Introverted Don Johnston receives an anonymous letter from an ex-lover informing him that he has a son who may be looking for him. A freelance sleuth neighbor motivates Don to embark on a cross-country search for his past flames seeking answers.

Unwilling to let his daughter attend a high school trip unsupervised, a protective father and his charismatic mother-in-law show up to crash the party.

A recovering gambling addict attempts to reconcile with his family and friends but finds trouble and temptation when caught between feelings for his ex-wife and her dangerous hoodlum boyfriend.

Dumped by his girlfriend and finding himself stranded on different couches at friends’ places, Guido tries to transform his drift into an opportunity for a new beginning.

Mabel Longhetti, desperate and lonely, is married to a Los Angeles municipal construction worker, Nick. Increasingly unstable, especially in the company of others, she craves happiness, but her extremely volatile behavior convinces Nick that she poses a danger to their family and decides to commit her to an institution for six months. Alone with a trio of kids to raise on his own, he awaits her return, which holds more than a few surprises.

Six months into a solo mission, a lonely astronaut confronts the cracks in his marriage with help from a mysterious creature he discovers on his ship.

After the murder of his beloved wife, a man in search of redemption is set adrift in a world where nothing is as it seems. On his journey, he befriends slacker Jimmy "The Finn", becomes involved in rescuing his neighbor Colette from her own demons, and gets entangled in a web of deceit full of unexpected twists and turns.

When an alien takes the form of a young widow's husband and asks her to drive him from Wisconsin to Arizona, the government tries to stop them.

Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends --Sick Boy, Begbie, Spud and Tommy. He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind as Begbie and Sick Boy come knocking.

José Sirgado is a low-budget filmmaker whose heroin addiction distorts his perspective of the real world. Although he is a depressed and unstable individual, his mood improves when he receives the mysterious films of Pedro, with whom he shares his passion for cinema.

The story of a heartbroken man who attends a spiritual retreat, only to discover that the course releases more than everyday toxins and traumatic experiences.

A young half-Navajo convict dying of cancer forces a yuppie doctor to drive him to a magic healing lake.

When a deadly airborne virus threatens to wipe out the northeastern United States, teacher Elliot Moore and his wife Alma flee from contaminated cities into the countryside in a fight to discover the truth. Is it terrorism, the accidental release of some toxic military bio weapon -- or something even more sinister?

A world-weary college professor is given a life-changing diagnosis and decides to throw all pretense and conventions to the wind and live his life as boldly and freely as possible with a biting sense of humor, a reckless streak and a touch of madness.

Barely escaping an avalanche during a family ski vacation in the Alps, a married couple is thrown into disarray as they are forced to reevaluate their lives and how they feel about each other.

A bigoted junkie cop suffering from borderline personality disorder and drug addiction manipulates and hallucinates his way in a bid to secure promotion.

After getting into a car accident while drunk on the day of her sister's wedding, Gwen Cummings is given a choice between prison or a rehab center. She chooses rehab, but is extremely resistant to taking part in any of the treatment programs they have to offer, refusing to admit that she has an alcohol addiction.

Corporate billionaire Edward Cole and working class mechanic Carter Chambers are worlds apart. At a crossroads in their lives, they share a hospital room and discover they have two things in common: a desire to spend the time they have left doing everything they ever wanted to do and an unrealized need to come to terms with who they are. Together they embark on the road trip of a lifetime, becoming friends along the way and learning to live life to the fullest, with insight and humor.

An exploration of the United States of America's war on drugs from multiple perspectives. For the new head of the Office of National Drug Control Policy, the war becomes personal when he discovers his well-educated daughter is abusing cocaine within their comfortable suburban home. In Mexico, a flawed, but noble policeman agrees to testify against a powerful general in league with a cartel, and in San Diego, a drug kingpin's sheltered trophy wife must learn her husband's ruthless business after he is arrested, endangering her luxurious lifestyle.

After their airplane crashes behind enemy lines, four soldiers must survive and try to find a way back to their battalion. However, when they come across a local peasant girl the horrors of war quickly become apparent.

An airline pilot and his wife are forced to face the consequences of her alcoholism when her addictions threaten her life and their daughter's safety. While the woman enters detox, her husband must face the truth of his enabling behavior.

After a blow to the head, Abby decides she can't do it anymore. Her life just can't be only about the house, the kids and the wife. She needs more: she needs to be Eleanor.

A blind man who regains his vision finds himself becoming metaphorically blinded by his obsession for the superficial.

A man who has been having visions of an impending danger begins an affair with a woman who may lead him to his doom.

While vacationing on a remote German island with his younger pregnant wife, an artist has an emotional breakdown while confronting his repressed desires.

A man's life is turned inside out after a visit from his college friend leads him into the unexpected.

Pressured by his late mother's ghost to return home to the family he abandoned, a former addict grabs a bag of pills and a sack of marijuana and hits the road to Shreveport.

On a road trip, Nic and two friends are drawn to an isolated area by a computer genius. When everything suddenly goes dark, Nic regains consciousness – only to find himself in a waking nightmare.

On the run after committing murder, an accountant encounters a strange Native American man who prepares him for his journey into the spiritual world.

A drunken, self-destructive woman called Betty wanders into a Parisian bar where she meets middle-aged alcoholic Laure. Laure decides to take care of Betty. Recovering in a hotel room, Betty begins to recount to Laure the story of her bourgeois life and her unhappy and unfaithful marriage.

As an asteroid nears Earth, a man finds himself alone after his wife leaves in a panic. He decides to take a road trip to reunite with his high school sweetheart. Accompanying him is a neighbor who inadvertently puts a wrench in his plan.

Victor is a legal advisor who finds himself abandoned by his wife and fired the same day. He tries to seek comfort from different friends and family members, but everyone he meets is concerned with their own problems. His morale begins to falter when he realizes that no one cares about him.

Self-described misanthrope Elle Reid has her protective bubble burst when her 18-year-old granddaughter, Sage, shows up needing help. The two of them go on a day-long journey that causes Elle to come to terms with her past and Sage to confront her future.

Rattled by sudden unemployment, a Manhattan couple surveys alternative living options, ultimately deciding to experiment with living on a rural commune where free love rules.

Undercover cop Jim Raynor is a seasoned veteran. His partner, Kristen Cates, is lacking in experience, but he thinks she's tough enough to work his next case with him: a deep cover assignment to bring down the notoriously hard-to-capture drug lord Gaines. While their relationship turns romantic during the assignment, they also turn into junkies, and will have to battle their own addictions if they want to bring down Gaines once and for all.

Two miners agree to guide a mysterious woman, who has appeared in their camp from nowhere, to a nearby town; but soon, because of her erratic behavior, they begin to suspect that her true purpose is quite different.

Two middle-aged men embark on a spiritual journey through Californian wine country. One is an unpublished novelist suffering from depression, and the other is only days away from walking down the aisle.

John LeTour is a recovering drug user who suffers insomnia and still deals to a high-end New York clientele, even though he’s trying to move on from the business. John’s professional midlife crisis becomes something more acute — and dangerous — when he re-encounters an old flame while a string of seemingly drug-related murders rocks the city.

An aging, booze-addled father takes a trip from Montana to Nebraska with his estranged son in order to claim what he believes to be a million-dollar sweepstakes prize.

Following the unexplained suicide of his wife Liza, website designer Wilson Joel turns to huffing gasoline fumes and remote control gaming while avoiding an inevitable conflict with his mother-in-law.

A brother and sister are sent to their grandparents' remote Pennsylvania farm for a week, where they discover that the elderly couple is involved in something deeply disturbing.

The story of two brothers: one who’s devoted to his family, the other who’s obsessed with the Manson Family.

While dining out with friends, Sy suggests the difficulty of separating comedy from tragedy. To illustrate his point, he tells his guests two parallel stories about Melinda ; both versions have the same basic elements, but one take on her state of affairs leans toward levity, while the other is full of anguish. Each story involves Melinda coping with a recent divorce through substance abuse while beginning a romantic relationship with a close friend's husband.

A divorced writer from the Midwest returns to her hometown to reconnect with an old flame, who's now married with a family.

Taking a break from their dreary lives, close friends Thelma and Louise embark on a short weekend trip that ends in unforeseen incriminating circumstances. As fugitives, both women rediscover the strength of their bond and their newfound resilience.

Dr. Alan Feinstone has everything: a beautiful wife and a successful career in dentistry. However, when he discovers his wife's affair, he realizes that behind every clean, white surface lies the stench of decay.

An American couple drift toward emptiness in postwar North Africa.

A debauched Hollywood movie actor tries to piece together one wild night in Miami years earlier which remains a drug-induced blur, and soon finds out that some questions about his past are best left unanswered.

A gallerist risks her family and flourishing career when she enters into an affair with a talented painter and slowly loses control of her life.

Brian comes under the addictive spell of a parasite with the ability to induce euphoric hallucinations in its hosts.

Life for a happy couple is turned upside down after their young son dies in an accident.

Two men, part tramp, part pilgrim, are on their way to Santiago de Compostela in Spain. On their way they meet a whole assortment of people—some truculent, some violent, and some bizarre; they experience many adventures—some mysterious, some erotic, some even supernatural.

Over the course of three days Ross, a college dropout addicted to crystal-meth, encounters a variety of oddball folks - including a stripper named Nikki and her boyfriend, the local meth producer, The Cook - but all he really wants to do is hook up with his old girlfriend, Amy.

A disgraced FBI agent with a drinking problem joins nine other troubled law enforcement officers at an isolated detox clinic in the wilds of Wyoming. But the therapeutic sanctuary becomes a nightmarish hellhole when a major snowstorm cuts off the clinic from the outside world and enables a killer on the inside to get busy.

Bailey and Darla embark upon a misguided and mutually deceitful form of therapy, one in which they must drive across the country, re-enacting Darla's colorful history as a sex addict. As their true motivations for the road trip come to light, the unlikely pair force one another to confront their issues, discovering that there might actually be more to love than just sex.

Alexander, a journalist, philosopher and retired actor, celebrates a birthday with friends and family when it is announced that nuclear war has begun.